ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Effector protein NleF

Intermolecular
Cysteine 287 of Caspase-9 and cysteine 188
A redox-regulated disulphide may form between cysteine 287 of Caspase-9 and cysteine 188 of Effector protein NleF (285 and 188 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
52
PDB code
3v3k
Structure name
human caspase 9 in complex with bacterial effector protein
Structure deposition date
2011-12-13
Thiol separation (Å)
5
Half-sphere exposure sum ?
90
Minimum pKa ?
11
% buried
100
Peptide A name
Caspase-9
Peptide B name
Effector protein NleF
Peptide A accession
P55211
Peptide B accession
Q8XAL7
Peptide A residue number
287
Peptide B residue number
188

Ligandability

Cysteine 287 of Caspase-9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 188 of Effector protein NleF

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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